World Library  

QR link for Plos One : Postnatal Leptin Promotes Organ Maturation and Development in Iugr Piglets, Volume 8
Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Postnatal Leptin Promotes Organ Maturation and Development in Iugr Piglets, Volume 8

By Rogers, Lynette, Kay

Click here to view

Book Id: WPLBN0003964936
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Postnatal Leptin Promotes Organ Maturation and Development in Iugr Piglets, Volume 8  
Author: Rogers, Lynette, Kay
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Rogers, L. K. (n.d.). Plos One : Postnatal Leptin Promotes Organ Maturation and Development in Iugr Piglets, Volume 8. Retrieved from http://community.worldlibrary.net/


Description
Description : Babies with intra-uterine growth restriction (IUGR) are at increased risk for experiencing negative neonatal outcomes due to their general developmental delay. The present study aimed to investigate the effects of a short postnatal leptin supply on the growth, structure, and functionality of several organs at weaning. IUGR piglets were injected from day 0 to day 5 with either 0.5 mg/kg/d leptin (IUGRLep) or saline (IUGRSal) and euthanized at day 21. Their organs were collected, weighed, and sampled for histological, biochemical, and immunohistochemical analyses. Leptin induced an increase in body weight and the relative weights of the liver, spleen, pancreas, kidneys, and small intestine without any changes in triglycerides, glucose and cholesterol levels. Notable structural and functional changes occurred in the ovaries, pancreas, and secondary lymphoid organs. The ovaries of IUGRLep piglets contained less oogonia but more oocytes enclosed in primordial and growing follicles than the ovaries of IUGRSal piglets, and FOXO3A staining grade was higher in the germ cells of IUGRLep piglets. Within the exocrine parenchyma of the pancreas, IUGRLep piglets presented a high rate of apoptotic cells associated with a higher trypsin activity. In the spleen and the Peyer’s patches, B lymphocyte follicles were much larger in IUGRLep piglets than in IUGRSal piglets. Moreover, IUGRLep piglets showed numerous CD79+cells in well-differentiated follicle structures, suggesting a more mature immune system. This study highlights a new role for leptin in general developmental processes and may provide new insight into IUGR pathology.

 

Click To View

Additional Books


  • Plos One : Formation of Asymmetrical Str... (by )
  • Plos One : Comparative Genomics of Serra... (by )
  • Plos One : Neutral Lipid Metabolism Infl... (by )
  • Plos One : Survey of Naegleria Fowleri i... (by )
  • Plos One : the Deoxyhypusine Synthase Mu... (by )
  • Plos One : Construction of Improved Tool... (by )
  • Plos One : the Success of Acinetobacter ... (by )
  • Plos One : Induced Sputum Mmp-1, -3 & -8... (by )
  • Plos One : Local Network Patterns in Pro... (by )
  • Plos One : Demarcation of Stable Subpopu... (by )
  • Plos One : Rotavirus Seasonality and Age... (by )
  • Plos One : Identification and Characteri... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.